PULMONARY EDEMA INDUCED BY ADRENALINE AND RELATED AMINES IN RATS, AND ITS MODIFICATION BY VARIOUS PRETREATMENTS

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Abstract
Acute pulmonary edema was induced in rats by intravenous infusion of epinephrine. Norepinephrine and methoxamine also induced pulmonary edema, but not isoproterenol. The edema production is almost exclusively connected to the alpha adrenergic action of these agents. Pre-treatments, including operative procedures, autonomic blocking agents, proteolytic enzymes and their inhibitors, were screened for protective effect against the epinephrine induced pulmonary edema. Phenoxy-benzamine, pithing, ligation of the portal vein and bromelain were effective. Possible significance of these findings were discussed with regard to the pathogenesis of the pulmonary edema.