Structure-activity relationships among negamycin analogs.

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Abstract
Various negamycin analogs were examined for miscoding activity and inhibition of the termination of protein synthesis [with an Escherichia coli in vitro system]. Since these properties do not correlate for the investigated compounds they may depend on different structural features of negamycin analogs. The results of biochemical and antimicrobial studies indicate that the natural configuration of the C atom carrying the .beta.-amino group is essential, the .delta.-hydroxyl group is unnecessary and the acylation of the .epsilon.-amino group causes loss of activity.

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