Bidirectional urate transport limited to the proximal tubule in dogs

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Abstract
Urate and inulin were infused into renal arteries during stop-flow occlusions. More urate than inulin appeared in samples representing proximal tubular fluid. This was reversed by prior administration of PAH [para-amino hippurate], chlorothiazide, or salicylate. There is a secretory flux for urate which is mediated by the organic anion transport carrier. During PAH administration when cyanide was infused into the renal artery, net reabsorptive transport of urate was converted to net secretory transport. This and other evidence led to the conclusion that reabsorption involves active transport.

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