THE EFFECT OF A PROLINE-RICH POLYPEPTIDE (PRP) ON THE HUMORAL IMMUNE-RESPONSE .2. PRP INDUCES DIFFERENTIATION OF HELPER-CELLS FROM GLASS-NONADHERENT THYMOCYTES (NAT) AND SUPPRESSOR CELLS FROM GLASS-ADHERENT THYMOCYTES (GAT)

  • 1 January 1984
    • journal article
    • research article
    • Vol. 32  (2) , 197-201
Abstract
Normal mice given thymocyte subpopulations preincubated with a proline-rich polypeptide (PRP) and immunized with SRBC [sheep red blood cells] show enhanced or suppressed humoral immune response measured by the number of plaque-forming cells (PFC). PRP induces differentiation of cells exhibiting helper or suppressor function from NAT and GAT, respectively. Moreover, PRP-induced helper cells lost their activity after treatment with anti-Lyt 1.1, and the PRP-induced suppressor cells after treatment with anti-Lyt 2.1, monoclonal antibodies.