TUMOR PREVENTION IN XERODERMA PIGMENTOSUM WITH AROMATIC RETINOID (RO 10-9359)

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 33  (8) , 445-448
Abstract
The aromatic retinoid Ro 10-9359 [ethyl-all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate], 1 mg/kg body wt, was given to an 11-yr-old girl with xeroderma pigmentosum. Therapy resulted in disappearance of actinic keratoses and basal cell carcinomas. The occurrence of new tumors was prevented in this patient while she participated in this preventive therapy for 7 mo. The reduction of the aromatic retinoid to 0.4 mg/kg body wt every other day resulted in the reappearance of 4 basal cell carcinomas and 1 keratoacanthoma within 6 wk.