Preparation of 10-Trifluoromethyl Artemether and Artesunate. Influence of Hexafluoropropan-2-ol on Substitution Reaction
- 19 November 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (25) , 9763-9766
- https://doi.org/10.1021/jo035174o
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Highly enantioselective catalytic Michael reaction of α-substituted malonates using La-linked-BINOL complex in the presence of HFIP (1,1,1,3,3,3-hexafluoroisopropanol)Tetrahedron Letters, 2002
- First Synthesis of 10α-(Trifluoromethyl)deoxoartemisininOrganic Letters, 2002
- Intramolecular SN2 reaction α- to a trifluoromethyl group: preparation of 1-cyano-2-trifluoromethylcyclopropaneTetrahedron: Asymmetry, 1999
- Fluorinated Synthons: Reactivity of 1-RF-Epoxy Ethers with Lewis AcidsThe Journal of Organic Chemistry, 1995
- Fluorine-Directed Nazarov Cyclizations: A Controlled Synthesis of Cross-Conjugated 2-Cyclopenten-1-onesThe Journal of Organic Chemistry, 1995
- Nouvelle Classe de Sucres a Liaison Osidique Stabilisee : 1-Desoxy-1,1,1-trifluoro-pent(hex)-2-uloses; Obtention de Quelques DerivesJournal of Carbohydrate Chemistry, 1994
- Electronegatively substituted carbocationsChemical Reviews, 1991
- Reactions of 2-vinylindoles with carbodienophiles: synthetic and mechanistic aspectsThe Journal of Organic Chemistry, 1990
- Qinghaosu (Artemisinin): an Antimalarial Drug from ChinaScience, 1985
- Linear solvation energy relationships. 23. A comprehensive collection of the solvatochromic parameters, .pi.*, .alpha., and .beta., and some methods for simplifying the generalized solvatochromic equationThe Journal of Organic Chemistry, 1983