Reversed-Phase High-Performance Liquid Chromatographic Separation of 3-O-Acyloxazepam and Its Hydrolysis and Alcoholysis Products

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Abstract
A reversed-phase high performance liquid chromatographic system was developed to separate oxazepam and its 3-O-acyl and 3-O-alkyl (alkyl = methyl, ethyl, isopropyl, n-propyl, sec-butyl, isobutyl, n-butyl, and n-pentyl) derivatives. The chromatographic conditions established a simple analytical method for monitoring the kinetics in the hydrolysis and alcoholysis of 3-O-acyloxazepam (oxazepam 3-acetate) under a variety of experimental conditions.