The Ototoxic Interaction of Viomycin, Capreomycin and Polymyxin B With Ethacrynic Acid

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Abstract
The ototoxic interaction between the aminoglycoside antibiotics [antibacterials] (streptomycin, kanamycin, etc.) and the loop-inhibiting diuretics (ethacynic acid, furosemide and bumetanide) causes extensive destruction of the hair cells of the cochlea. This interaction does not occur with the non-loop-inhibiting diuretics and kanamycin. To determine if antibiotics other than the aminoglycosides could produce the ototoxic interaction when combined with a loop-inhibiting diuretic, viomycin, capreomycin and polymyxin B were given to guinea pigs with ethacrynic acid; they produced cochlear hair cell damage similar to that produced by aminoglycoside antibiotics administered with ethacrynic acid. The interaction appears to be specific to the loop-inhibiting diuretics but not specific for the aminoglycoside antibiotics.