Interaction of Kanamycin and Ethacrynic Acid: Severe Cochlear Damage in Guinea Pigs

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Abstract
The clinical observation that ethacrynic acid administration to patients receiving kanamycin therapy can result in a permanent hearing loss has been verified in experimental animals. We have demonstrated that guinea pigs receiving a loading dose of 400 mg/kg of kanamycin subcutaneously, followed in two hours by an intravenous injection of 40 mg/kg of ethacrynic acid, lose their cochlear function permanently. The effect occurs approximately two hours after the injection of ethacrynic acid and seems to occur by a different mechanism than that which produces the initial temporary effect previously reported. Because of this possible interaction, caution must be exercised when employing an aminoglycoside antibiotic and ethacrynic acid together in patients with renal failure.

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