Antibacterial characteristics of YTR 830, a sulfone beta-lactamase inhibitor, compared with those of clavulanic acid and sulbactam
- 1 June 1988
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 32 (6) , 925-927
- https://doi.org/10.1128/aac.32.6.925
Abstract
The antibacterial activity, binding to penicillin-binding proteins, and morphological changes effected by YTR 830, a sulfone beta-lactamase inhibitor, were studied in comparison with those of other beta-lactamase inhibitors. YTR 830 had very poor antibacterial activity, bound to PBP 2 of gram-negative organisms, and at the MIC caused rapid lysis of spheroplasts formed.This publication has 13 references indexed in Scilit:
- Improved sensitivity in assays for binding of novel beta-lactam antibiotics to penicillin-binding proteins of Escherichia coliAntimicrobial Agents and Chemotherapy, 1987
- Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamasesAntimicrobial Agents and Chemotherapy, 1986
- Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillinAntimicrobial Agents and Chemotherapy, 1984
- Affinity of temocillin for Escherichia coli K-12 penicillin-binding proteinsAntimicrobial Agents and Chemotherapy, 1984
- In vitro activities of new beta-lactam antibiotics against Acinetobacter sppAntimicrobial Agents and Chemotherapy, 1983
- Growth curve patterns and bacterial morphology of Escherichia coli subjected to different temocillin (BRL17421) concentrationsJournal of Antimicrobial Chemotherapy, 1982
- In-vitro evaluation of sulbactam, a penicillanic acid sulphone with β-lactamase inhibitory propertiesJournal of Antimicrobial Chemotherapy, 1982
- Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activityAntimicrobial Agents and Chemotherapy, 1979
- Properties of the Penicillin‐Binding Proteins of Escherichia coli K12European Journal of Biochemistry, 1977
- Maturation of the head of bacteriophage T4Journal of Molecular Biology, 1973