Generation of interleukin‐8 by plasmin from AVLPR‐interleukin‐8, the human fibroblast‐derived neutrophil chemotactic factor
- 6 May 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 282 (2) , 412-414
- https://doi.org/10.1016/0014-5793(91)80526-9
Abstract
Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.Keywords
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