Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae
Open Access
- 24 January 2008
- journal article
- Published by Springer Nature in BMC Neuroscience
- Vol. 9 (1) , 13
- https://doi.org/10.1186/1471-2202-9-13
Abstract
Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptotic pathways in both pro- and anti-apoptotic fashions. We have hypothesized that persistent chlamydial infection of neurons may be an important mediator of the characteristic neuropathology observed in AD brains. Chronic and/or persistent infection of neuronal cells with C. pneumoniae in the AD brain may affect apoptosis in cells containing chlamydial inclusions.Keywords
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