Effect of Saturated and Unsaturated Fatty Acids on Dietary Lipogranuloma

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Abstract
Occurrence of lipogranuloma, a foreignbody type reaction in adipose tissue, has been studied in rats fed diets containing ratios of unsaturated to saturated fatty acid ranging from zero (diet containing only saturated fat as acetylated monoglycerides made from hydrogenated lard) to 3.0 (diet containing a mixture of equal parts of corn oil and lard). The earliest observed occurrence of lipogranuloma was at two weeks, on the diet containing completely saturated fat. Fat-cell reaction did not appear to a significant degree when the ratio of unsaturated to saturated fatty acid was 1.0 or greater, but it increased in incidence and severity as the ratio decreased below 1.0.

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