EFFECT OF PLASMA FROM HYPOPHYSEAL-PORTAL VESSEL BLOOD ON ADRENAL ASCORBIC ACID1

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Abstract
THERE is lack of unanimity of opinion regarding the relative significance of different factors in the regulation of secretion of the adrenocorticotrophic hormone (ACTH) (Long, 1952). Much suggestive evidence, however, implicates the hypothalamus as being of importance, perhaps by way of a neurohumoral substance (Hinsey and Markee, 1933 and Green and Harris, 1947). The existence of vascular connections, a portal system, transporting blood from the hypothalamus to the anterior lobe of the pituitary is established (Wislocki and King, 1936; Green and Harris, 1947, 1949; and Xuereb et al., 1954). Harris and Jacobsohn (1952) and Jacobsohn (1954) using pituitary transplants in the rat and rabbit respectively have suggested that function of the anterior lobe is dependent upon vascular connections between the pituitary and median eminence. Although results have varied somewhat, destructive lesions in different sites of the hypothalamus have been reported by several investigators to inhibit the release of ACTH by the experimental animal in response to stressful conditions (De Groot and Harris, 1950; Hume and Wittenstein, 1950; Porter, 1953; McCann, 1953; McCann and Sydnor, 1954; Ganong and Hume, 1954; and Laqueur et al., 1955).