Conversion of Mouse Mammary Tumor Virus to a Lymphomagenic Virus
- 1 October 2005
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 79 (19) , 12592-6
- https://doi.org/10.1128/jvi.79.19.12592-12596.2005
Abstract
Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regulatory elements (NREs) or by suppression of NRE activity after appropriate positioning of the enhancer.Keywords
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