CROSS-PROTECTION AGAINST SALMONELLA ENTERITIDIS INFECTION IN MICE .2. HUMORAL IMMUNE-RESPONSE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 26  (4) , 283-291
Abstract
Mice were immunized s.c. with live vaccines and live vaccines with complete adjuvant incorporating S. enteritidis Se795, S. typhimurium M206, S. gallinarum 9R or S. pullorum Sp223. They were challenged along with unvaccinated controls with 100 LD50 of virulent S. enteritidis 5694 SMR s.c. on the 21st day post-vaccination. The humoral immune response was studied by assessing the sequential level of agglutinins, complete and incomplete somatic antibodies, opsonophagocytic antibodies, cytophilic antibodies and bactericidal antibodies before and after challenge. The level of these antibodies and the protection afforded by the particular vaccine is correlated and the possible involvement of a humoral mechanism is discussed.