SPLENIC LYMPHOCYTE DISCHARGE INDUCED BY ADRENAL CORTICAL HORMONES UNDER IN VIVO CONDITIONS1

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Abstract
In a preceding paper, it was demonstrated that adrenal cortex extract (ACE) produces lymphocyte discharge from the perfused rabbit spleen (Hechter, 1948). It was therefore of interest to determine whether ACE produces a similar reaction upon the spleen under in vivo conditions. In this connection, our attention was drawn to the fact that some stresses appear to be associated with an absolute lymphocytosis, instead of the lymphopenia which has been more commonly associated with increased adrenal cortical activity (cf. White and Dougherty, 1946). Thus, absolute lymphocytosis has been reported following: exercise in rats and mice (Harlow and Selye, 1937) and in man (cf. Garrey and Bryan, 1935), short-term (five minute) restraint in rats (Farris, 1938b), and so-called “emotional stimulation” in man (Farris, 1938a). In view of our in vitro findings, it seemed possible that the lymphocytosis associated with these stress situations might in part result from a possible action of adrenal cortical hormone (ACH) upon the splenic lymphocyte discharge mechanism.

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