LYMPHOCYTE DISCHARGE FROM THE ISOLATED RABBIT SPLEEN BY ADRENAL CORTICAL EXTRACT

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Abstract
The admn. of adrenal cortex extract to the isolated rabbit spleen, perfused with whole blood at a constant mean pressure, induces a prompt discharge of splenic lymphocytes into the circulation. There is, secondarily, a tendency for the level of circulating lymphocytes in the perfusion medium to fall. The secondary decrease in lymphocyte count appears to be due to accelerated lymphocyte breakdown by spleen, in the presence of ACE. The activity of ACE to produce the in vitro reaction upon spleen is not associated with alteration of mean arterial pressure or changes in splenic flow, and can be demonstrated upon repetitive addition of ACE. The addition of ACE to perfused thymus, liver, or lung does not produce discharge of lymphocytes from these tissues; glucose, epinephrine, desoxycorticosterone acetate, and es-tradiol dipropionate in the doses tested, did not provoke lymphocyte discharge from spleen.

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