The Interrelationship of Manganese, Phosphatase and Vitamin D in Bone Development

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Abstract
In rachitic chicks it was found that the bone phosphatase is increased to an abnormally high level the same as in the rachitic rat. By omitting manganese from the rachitogenic diet, the bone phosphatase was decreased to approximately the normal amount. The difference in the phosphatase levels in the bones of groups of chicks fed rachitogenic diets, with and without an adequate quantity of manganese, was found to be much greater than the difference in the phosphatase levels in the bones of groups of chicks fed a non-rachitogenic diet, with and without an adequate quantity of manganese.