Bypass by an alternate ‘carrier’ of acquired unresponsiveness to hCG upon repeated immunization with tetanus-conjugated vaccine

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Abstract
We report here the use of an alternative cariler diphtheria toxoid (DT) In human subjects to overcome antigen-specific unresponsiveness upon Immunization with a hapten/ligand-carrier conjugate. In the phase I clinical trial of a birth control vaccine using gonadotrophin subunits linked to tetanus toxoid, some of the subjects failed to evoke a booster antibody response to human chorlonic gonadotrophin (hCG). Presentation of the ligand on DT Instead In subsequent Immunizations restored anti-hCG response.

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