PRO-INFLAMMATORY FACTOR IN LYMPHOCYTES - ITS ROLE IN DEVELOPMENT OF ACUTE, NON-IMMUNOLOGICAL INFLAMMATORY REACTIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (4) , 377-386
Abstract
Drug-induced leukopenia renders rats hyporeactive to various inflammatory stimuli. Administration to leukopenic rats of suspensions of lymphocytes, sufficient to apparently correct the induced lymphocytopenia, led to a partial but marked reversal of the inhibited responses. Similar results were observed when lysates of lymphocytes or filtrates of the disintegrated cells were injected. Suspensions of polymorphonuclear granulocytes, on the contrary, were ineffective in producing a reversal of inhibited inflammatory reactions in leukopenic rats. The presence of a proinflammatory factor (LpIF) in lymphocytes, which might be involved in the modulation of acute inflammatory responses is suggested.