Chemoenzymatische Synthese fluoreszierender N‐Ras‐Lipopeptide und ihre Verwendung bei In‐vivo‐Studien zur Membranlokalisierung
- 17 October 1997
- journal article
- Published by Wiley in Angewandte Chemie
- Vol. 109 (20) , 2334-2337
- https://doi.org/10.1002/ange.19971092028
Abstract
Spezifisch in der Plasmamembran akkumulieren S‐farnesylierte und S‐palmitoylierte N‐Ras‐Lipopeptide 1 (der ausgefüllte Kreis symbolisiert eine fluoreszierende Gruppe), wie durch fluoreszenzmikroskopische Untersuchungen an Fibroblastenzellen gezeigt wurde. Ausschließlich S‐farnesylierte Lipopeptide akkumulieren hingegen nicht in der Plasmamembran. magnified imageKeywords
This publication has 44 references indexed in Scilit:
- Enzymatic Synthesis of Peptide Conjugates: Tools for the Study of Biological Signal TransductionEuropean Journal of Organic Chemistry, 1997
- Purification of a Protein Palmitoyltransferase that Acts on H-Ras Protein and on a C-terminal N-Ras PeptidePublished by Elsevier ,1996
- Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells.The Journal of cell biology, 1996
- Biochemical Characterization of a Palmitoyl Acyltransferase Activity That Palmitoylates Myristoylated ProteinsJournal of Biological Chemistry, 1995
- Transport into and out of the Golgi complex studied by transfecting cells with cDNAs encoding horseradish peroxidase.The Journal of cell biology, 1994
- Effects of Carboxy-Terminal Truncation on the Stability and G Protein-Coupling Activity of Bovine RhodopsinBiochemistry, 1994
- Proteins regulating Ras and its relativesNature, 1993
- Characterization of an acyltransferase acting on p21N-ras protein in a cell-free systemBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1991
- Transport of cholesterol from the endoplasmic reticulum to the plasma membrane.The Journal of cell biology, 1985
- Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylationPublished by Elsevier ,1983