Proteins regulating Ras and its relatives
- 16 December 1993
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 366 (6456) , 643-654
- https://doi.org/10.1038/366643a0
Abstract
GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and action. Their functions depend on their ability to alternate between inactive and active forms, and on their cellular localization. Numerous proteins affecting the GTPase activity, nucleotide exchange rates and membrane localization of Ras superfamily members have now been identified. Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.Keywords
This publication has 110 references indexed in Scilit:
- dbEST — database for “expressed sequence tags”Nature Genetics, 1993
- Oncogene ect2 is related to regulators of small GTP-binding proteinsNature, 1993
- MRS6 — yeast homologue of the choroideraemia geneNature Genetics, 1993
- A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4Nature, 1993
- DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p functionNature, 1993
- Both stimulatory and inhibitory GDPGTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteinsBiochemical and Biophysical Research Communications, 1992
- Identification and partial purification of GTPase‐activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteinsFEBS Letters, 1991
- The GTPase superfamily: conserved structure and molecular mechanismNature, 1991
- Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding proteinBiochemical and Biophysical Research Communications, 1989
- Tissue distribution of smg p25A, a ras p21-like GTP-binding protein, studied by use of a specific monoclonal antibodyBiochemical and Biophysical Research Communications, 1989