Skeletal Renewal and Metabolic Bone Disease

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Abstract
Adrenocortical SteroidsNowhere in the study of skeletal responses is the influence of species specificity more apparent than in the responses to perturbations in circulating levels of adrenocortical steroids. The rabbit becomes markedly osteopenic when given cortisone,89 but the intact dog does not, even if very high doses of steroids are used. Increased or decreased density of metaphyseal bone can be produced in rats given exogenous cortical steroids, depending on the calcium and phosphorus intake.90 The conclusion of Follis91 that the zone of increased density in the metaphyseal area of cortisone-treated rats as compared with pair-fed controls was due to . . .