Cell surface expression of the env gene polyprotein of dual-tropic mink cell focus-forming murine leukemia virus

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Abstract
Differences were observed in the kinetics of processing of the env gene polyprotein of ecotropic, xenotropic and dual-tropic mink cell focus-forming (MCF) murine leukemia virus. In pulse-chase experiments, the env gene polyprotein of the dual-tropic MCF virus exhibited a marked increase in stability relative to that of either ecotropic or xenotropic virus. A comparison of cell surface expression of env gene products of ecotropic, xenotropic and dual-tropic MCF murine leukemia virus was made. Only gp[glycoprotein]70 was accessible to lactoperoxidase-catalyzed radioiodination of [mouse and mink] fibroblasts infected by ecotropic or xenotropic virus, whereas both gp70 and the env gene polyprotein was expressed on the surface of dual-tropic MCF virus-infected cells.