Transport of antimicrobial agents using peptide carrier systems: anticandidal activity of m-fluorophenylalanine-peptide conjugates
- 1 December 1983
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 26 (12) , 1725-1729
- https://doi.org/10.1021/jm00366a013
Abstract
A series of di- and tripeptides containing D- and L-m-fluorophenylalanine was prepared and tested in vitro for the ability to inhibit the growth to the yeast Candida albicans. Peptides containing L-m-fluorophenylalanine inhibited the growth of C. albicans with minimum inhibitory concentrations (MIC) ranging from 0.5-63 .mu.g/ml. The parent L-m-fluorophenylalanine and peptides containing D-m-fluorophenylalaine were inactive (MIC > 250 .mu.g/ml) in these tests. The results of competitive antagonism studies supported peptide transport mediated entry of the inhibitory peptides, followed by release of L-m-fluorophenylalanine inside the cell.This publication has 7 references indexed in Scilit:
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