Alterations in the antigenic constitution of renal glomerular capillaries accompanying the histological maturation of renal glomeruli in the rat.

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Abstract
Fluorescein conjugates prepared from rabbit antiadult rat renal glomerulus and rabbit anti-adult rat splenic reticulum antisera were non-specifically absorbed with human renal connective tissue or cross-absorbed with connective tissues obtained from 1.0 cm. rat embryos. These preparations were applied to sections cut from kidneys of adult, young, neo-natal, and 3.0 cm. embryonic rats. Both of the non-specially absorbed conjugates stained capillaries of fully developed and incompletely developed glomeruli. The cross-absorbed anti-glomeruhis conjugate stained capillaries in fully developed but not in newly developing glomeruli. The cross-absorbed anti-splenic reticulum preparation produced faint capillary staining in fully developed glomeruli is accompanied by an alteration in the antigenic constitution of their capillaries.