EFFECTS OF SOMATIC COMPONENT OF PSEUDOMONAS-AERUGINOSA ON PROTECTIVE IMMUNITY IN EXPERIMENTAL MOUSE BURN INFECTION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 50  (1) , 53-61
Abstract
In a mouse burn model, a 3-component vaccine consisting of elastase toxoid, protease toxoid and the common antigen [Ag] (OEP) of P. aeruginosa was significantly effective on protection against s.c. injection with strain IFO 3455, but not with strains M2 or PF 2243. Somatic Ag of strains M2 and PF 2243 did not contain serological Ag cross-reacting with OEP. The protective effects of the somatic Ag of strain M2 were investigated. Formalin- and heat-killed Ag demonstrated significant protection against challenge with strain M2 in the mouse burn model. As strains PF 2243 and M2 belong to the same serotype 16 of Homma''s schema, somatic Ag of serotype 16 are probably devoid of OEP. The somatic component of P. aeruginosa may be essential to the effects of the multi-component vaccines on protective immunity.