Amphotericin B Potentiation of Rifampicin as an Antifungal Agent against the Yeast Phase of Histoplasma capsulatum

25 August 1972

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 177 (4050) , 709-710
https://doi.org/10.1126/science.177.4050.709

Abstract

Rifampicin, at high concentrations, inhibited growth and RNA synthesis in the yeast phase of Histoplasma capsulatum . These effects were potentiated by low concentrations of amphotericin B. The combination of the two agents was fungicidal, whereas each alone, at much higher concentrations, was only fungistatic.

Keywords

AMPHOTERICIN
FUNGISTATIC
FUNGICIDAL
ANTIFUNGAL AGENT
POTENTIATION OF RIFAMPICIN
YEAST
CAPSULATUM

This publication has 3 references indexed in Scilit:

Progressive disseminated histoplasmosis as seen in adults
The American Journal of Medicine, 1970
Cell wall studies ofHistoplasma capsulatum
Medical Mycology, 1967
GROWTH OF THE YEASTLIKE PHASE OF HISTOPLASMA CAPSULATUM IN A FLUID MEDIUM
Journal of Bacteriology, 1950