Neuronal Proteins and Paraneoplastic Syndromes

Publisher Website
Google Scholar
Abstract
AN early manifestation of small-cell carcinoma of the lung and ovarian carcinoma is peripheral or central nervous system dysfunction — the so-called paraneoplastic syndromes — which is frequently encountered before the tumor is detected. Paraneoplastic syndromes affecting the central nervous system include the loss of visual acuity1 , 2 and cerebellar dysfunction3; in the peripheral nervous system, they include sensory neuronopathy4 and Lambert–Eaton myasthenic syndrome. This issue of the Journal contains two articles related to paraneoplastic syndromes associated with small-cell carcinoma of the lung: McEvoy and colleagues describe the efficacy of 3,4-diaminopyridine in the treatment of the Lambert–Eaton syndrome,5 and Thirkill . . .