Metabolische Zonierung des Leberparenchyms

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Abstract
The liver is the glucostat of the organism. It removes glucose when offered in excess as after a normal meal via glycogen synthesis and glycolysis; it provides glucose when needed as in between meals. Hepatocytes from the periportal (afferent) and perivenous (efferent) zones of the liver parenchyma differ in their enzyme content and subcellular structures. Therefore, the model of metabolic zonation proposes different functions for the 2 zones. Glucose release is predominantly located in the periportal and glucose uptake in the perivenous zone. The non-zonal, homogeneous and the zonal, heterogeneous organization of antagonistic pathways were compared to a marrow country road and a devided highway, respectively, which would allow traffic to proceed at a given time in only 1 or in both directions, respectively. The highway, corresponding to the model of metabolic zonation, is certainly more efficient than a narrow country road.