Cigarette Smoke Activates Guanylate Cyclase and Increases Guanosine 3′,5′-Monophosphate in Tissues
- 2 December 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 198 (4320) , 934-936
- https://doi.org/10.1126/science.22126
Abstract
The gaseous phase of cigarette smoke induced a 2- to 36-fold increase in the activity of guanylate cyclase in supernatant and particulate fractions from various rat and bovine tissues over basal activity. The characteristics of this phenomenon paralleled those of the activation of guanylate cyclase by nitric oxide, which is a component of tobacco smoke.This publication has 17 references indexed in Scilit:
- Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparationsProceedings of the National Academy of Sciences, 1977
- Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferensNature, 1977
- Calcium-Independent Modulation of Cyclic GMP and Activation of Guanylate Cyclase by NitrosaminesScience, 1976
- Increased Urinary Excretion of Cyclic Guanosine Monophosphate in Rats Bearing Morris Hepatoma 3924AScience, 1975
- The Role of Carbon Monoxide in Cigarette SmokingArchives of environmental health, 1975
- Increased particulate and decreased soluble guanylate cyclase activity in regenerating liver, fetal liver, and hepatoma.Proceedings of the National Academy of Sciences, 1975
- Induction of aryl hydrocarbon hydroxylase in the lungs of mice in response to cigarette smokeCellular and Molecular Life Sciences, 1973
- Adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate: concentrations in Morris hepatomas of different growth ratesBiochimica et Biophysica Acta (BBA) - General Subjects, 1973
- Cigarette smoke—A proposed metabolic lesion in alveolar macrophagesBiochemical Pharmacology, 1972
- Effects of Cigarette Smoke on the Ciliated Respiratory Epithelium of RatsRespiration, 1972