Increased Urinary Excretion of Cyclic Guanosine Monophosphate in Rats Bearing Morris Hepatoma 3924A
- 3 October 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 190 (4209) , 58-60
- https://doi.org/10.1126/science.170677
Abstract
Urinary excretion of cyclic guanosine monophosphate (GMP) increased in rats bearing Morris hepatoma 3924A, and a correlation coefficient of .842 was observed comparing nucleotide excretion and tumor size. Irradiation of tumor or 5-fluorouracil administration delayed the increases in urinary cyclic GMP and tumor size. Surgical removal of tumors resulted in a rapid decline in cyclic GMP excretion to baseline levels. Cyclic adenosine monophosphate excretion was not altered by implantation, irradiation, or excision of tumor.Keywords
This publication has 14 references indexed in Scilit:
- Activation of guanyl cyclase and intracellular cyclic GMP by fibroblast growth factorNature, 1974
- Effects of decapitation, ether and pentobarbital on guanosine 3′,5′-phosphate and adenosine 3′,5′-phosphate levels in rat tissuesBiochimica et Biophysica Acta (BBA) - General Subjects, 1974
- Possible involvement of cyclic GMP in growth control of cultured mouse cellsNature, 1974
- [7] Assay of cyclic nucleotides by receptor protein binding displacementPublished by Elsevier ,1974
- Increased cyclic GMP and decreased cyclic AMP levels in the hyperplastic, abnormally differentiated epidermis of psoriasisLife Sciences, 1973
- Pleiotypic Control by Cyclic AMP: Interaction with Cyclic GMP and Possible Role of MicrotubulesProceedings of the National Academy of Sciences, 1973
- Adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate: concentrations in Morris hepatomas of different growth ratesBiochimica et Biophysica Acta (BBA) - General Subjects, 1973
- Increased cyclic AMP levels in malignant hepatic nodules of ethionine treated ratsBiochemical and Biophysical Research Communications, 1972
- Guanosine 3′:5′-Cyclic Monophosphate: A Possible Intracellular Mediator of Mitogenic Influences in LymphocytesProceedings of the National Academy of Sciences, 1972
- Inhibition of Cell Growth in vitro by Adenosine 3′,5′-MonophosphateScience, 1968