Inhibition of Cell Growth in vitro by Adenosine 3′,5′-Monophosphate

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Abstract
Adenosine 3′,5′-monophosphate, at a concentration of 40 micrograms per milliliter, inhibits the growth of HeLa and strain L cells in culture. The inhibition becomes progressively greater during the incubation of the cells. Adenosine 5′-monophosphate and adenosine, metabolites of adenosine 3′,5′-monophosphate, do not affect the growth of either cell culture. This suggests that adenosine 3′,5′-monophosphate enters the cell without alteration. Dibutyryl-adenosine 3′,5′-monophosphate, reported to have a greater activity than adenosine 3′5′-monophosphate on several tissues, inhibited the growth of the cells much less.