Pleiotypic Control by Cyclic AMP: Interaction with Cyclic GMP and Possible Role of Microtubules
- 1 June 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (6) , 1659-1663
- https://doi.org/10.1073/pnas.70.6.1659
Abstract
Previous studies have shown that exogenous dibutyryl cyclic AMP inhibits the uptake of uridine, leucine, and 2-deoxyglucose by cultured mouse fibroblasts. 3':5'-cyclic GMP is shown here to counteract these inhibitory effects as well as the inhibition of precursor transport and leucine incorporation into proteins produced by prostaglandin E(1). We conclude, therefore, that cyclic GMP antagonizes the "pleiotypic" effects of cyclic AMP in these cells. Colcemid and vinblastine, but not cytochalasin B, reverse the transport inhibition caused by cyclic AMP without affecting the intracellular concentrations of cyclic AMP. These results suggest the possibility that cyclic AMP regulates the membrane transport of certain substrates by influencing the organization of microtubules.Keywords
This publication has 24 references indexed in Scilit:
- Pleiotypic Control by Adenosine 3′:5′-Cyclic Monophosphate: A Model for Growth Control in Animal CellsProceedings of the National Academy of Sciences, 1973
- Restoration of Several Morphological Characteristics of Normal Fibroblasts in Sarcoma Cells Treated with Adenosine-3′:5′-Cyclic Monophosphate and Its DerivativesProceedings of the National Academy of Sciences, 1971
- Morphological Transformation of Chinese Hamster Cells by Dibutyryl Adenosine Cyclic 3′:5′-Monophosphate and TestosteroneProceedings of the National Academy of Sciences, 1971
- Hydrolysis of Cyclic Guanosine and Adenosine 3',5'-Monophosphates by Rat and Bovine TissuesJournal of Biological Chemistry, 1970
- 5-Bromodeoxyuridine-Induced Differentiation of a NeuroblastomaProceedings of the National Academy of Sciences, 1970
- Cyclic AMP Receptor Protein of E. coli: Its Role in the Synthesis of Inducible EnzymesProceedings of the National Academy of Sciences, 1970
- Regulation of Axon Formation by Clonal Lines of a Neural TumorProceedings of the National Academy of Sciences, 1970
- Mechanism of Activation of Catabolite-Sensitive Genes: A Positive Control SystemProceedings of the National Academy of Sciences, 1970
- Effect of 3',5'-GMP and 3',5'-IMP on production of glucose and ammonia by renal cortexAmerican Journal of Physiology-Legacy Content, 1970
- Effect of adenosine 3′,5′-monophosphate on production of glucose and ammonia by renal cortexJournal of Clinical Investigation, 1969