THYROID FUNCTION TESTS IN ADULTS WITH DOWN'S SYNDROME

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Abstract
Thyroid status was studied in 24 patients above the age of 40 yr with Down''s syndrome; 3 patients had thyroid function tests indicating hypothyroidism, 8 patients had thyroid autoantibodies in serum and 8 patients had a higher than normal level of thyroid stimulating hormone [thyrotropin] in serum. None of the patients had figures indicating thyrotoxicosis and none showed any of the clinical signs usually seen in patients with hypothyroidism. Biochemical tests indicating hypothyroidism are much more often seen in patients with Down''s syndrome than in normal subjects and thyroid status should be assessed in old patients with this disease.

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