Experimental Coronary Arteriography

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Abstract
A study of arteriography of experimentally induced coronary arterial lesions requires a reliable method of producing such lesions in a model animal. Arterial lesions, often designated atherosclerotic, may result from repeated experimental vascular injuries by a variety of agents. A necrotizing arteritis may be produced, characterized by fibrinoid necrosis of the media and more or less cellular exudate involving the vessel wall and periadventitial tissues. The technics have included, among others, the induction of renal ischemia in dogs (4, 12), sensitization of rabbits by the injection of horse serum (8), and unilateral nephrectomy in rats, combined with injections of desoxycorticosterone (9). Segmental necrosis of the arterial wall following subcutaneous injection of trypsin has also been noted (7). While experimental atherosclerosis can be satisfactorily produced in a variety of animals, attempts to produce it in the dog have proved singularly difficult. Moreover, although the experimental production of...

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