Indomethacin and ascorbate inhibit desmoid tumors
- 1 September 1980
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 15 (1) , 85-90
- https://doi.org/10.1002/jso.2930150113
Abstract
Administration of indomethacin caused complete resolution of a desmoid tumor after a partial response to radiation. In another patient, this drug caused an immediate response, then became ineffective. When large doses of ascorbic acid were given with indomethacin, slow resolution of the tumor began and has continued for 14 months. Treatment of a third case with indomethacin and ascorbic acid from the beginning produced shrinkage of the tumor which has continued to date.Keywords
This publication has 20 references indexed in Scilit:
- Effect of ascorbic acid on ACTH-induced cyclic AMP formation and steroidogenesis in isolated adrrenal cells of vitamin E-deficient ratsBiochimica et Biophysica Acta (BBA) - General Subjects, 1975
- Treatment of Intra-abdominal and Abdominal Wall Desmoid Tumors With Drugs That Affect the Metabolism of Cyclic 3', 5'-Adenosine MonophosphateAnnals of Surgery, 1975
- PROSTAGLANDINS, KININ AND INFLAMMATION IN THE RATBritish Journal of Pharmacology, 1974
- ImmunologyPublished by Springer Nature ,1974
- The Inhibition by Aspirin and Indomethacin of Osteolytic Tumour Deposits and Hypercalcaemia in Rats with Walker Tumour, and its Possible Application to Human Breast CancerBritish Journal of Cancer, 1973
- The Role of Prostaglandins in the Immune ResponsePublished by Springer Nature ,1972
- Pro-Inflammatory Effects of Certain ProstaglandinsPublished by Springer Nature ,1972
- Prostaglandin Inhibition of Immediate and Delayed Hypersensitivity in VitroPublished by Springer Nature ,1972
- Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic DrugsPublished by Springer Nature ,1972
- Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like DrugsNature New Biology, 1971