Formation of Oxalate in Pyridoxine or Thiamin Deficient Rats during Intravenous Xylitol Infusions
- 1 March 1977
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 107 (3) , 458-465
- https://doi.org/10.1093/jn/107.3.458
Abstract
Glucose, fructose, sorbitol and xylitol were assessed as precursors of oxalate in normal rats and rats deficient in thiamin or vitamin B-6. Urinary excretions of oxalate, glyoxylate and glycine were increased significantly in vitamin B-6 deficient rats infused with xylitol when compared with all other groups. Using [U-14C]xylitol, oxalate was shown to be derived directly from this polyalcohol in vitamin B-6 deficient rats. These results suggest that vitamin B-6 deficiency may be a factor contributing to oxalate crystal deposition seen in some patients infused with xylitol.Keywords
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