Chemotherapeutic Activity of s-Triazines on Experimental Virus Infections

Publisher Website
Google Scholar
Abstract
The action of s-triazine derivatives in experimental type-B influenza virus and poliomyelitis virus infections (type 2) was studied. The results with compounds 2N-o-phenoxy-phenyl-amino-4-amino-I,3,5 triazine, 2N-p-phenoxy-phenyl-amino-4-amino-l,3,5 triazine and 2N-p-(4[image]-amino) phenoxy-benzyl-amino-4-amino-l,3,5 triazine were reported. In particular, the first compound protects (at a significantly high level) mice infected with type-B influenza virus when the compound is administered 24 hrs. before or 1 hr after infection. In experiments on deembryonated eggs, the compound slows the liberation of the virus from the infected cells and probably reduces the quantity produced. 2N-p-phenoxy-phenyl-amino-4-aminc-1,3,5 triazine had no activity in poliomyelitis virus infections in mice. The course of the absorption and elimination of 2-amino-4-morpholinyl-s-triazine (labelled with C14) was demonstrated.