EFFECTS OF COMBINED TREATMENT WITH DIETHYLDITHIOCARBAMATE AND DIHYDROXYETHYLDITHIOCARBAMATE ON DISTRIBUTION AND EXCRETION OF CADMIUM

  • 1 January 1983
    • journal article
    • research article
    • Vol. 41  (2) , 293-302
Abstract
Diethyldithiocarbamate (DDTC) rapidly mobilizes metallothionein-bound Cd from kidneys, liver and spleen, but promotes a redistribution which results in higher Cd burdens in lungs, testes and brain. Dihydroxyethyl-dithiocarbamate (DHDC) is less potent than DDTC in mobilizing renal Cd, but does not promote Cd redistribution to brain. Combined treatment with DDTC and DHDC, at half the mol dose of each when used alone, virtually effected as extensive renal Cd depletion as did DDTC alone, and slightly enhanced Cd mobilization from intestine and testes. Redistribution of Cd to brain was much less after combined treatment than was observed following treatment with DDTC alone.