Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus
- 1 June 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 297 (5866) , 479-483
- https://doi.org/10.1038/297479a0
Abstract
A normal human gene homologous to the p21 ras oncogene of Harvey murine sarcoma virus induced oncogenic transformation and high p21 ras levels in murine fibroblasts when this gene was ligated to a control element (the long terminal repeat) from a murine or feline retrovirus. These results indicate that high levels of a gene product encoded by a normal human oncogene can induce tumorigenic transformation.Keywords
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