STUDIES ON ADRENAL INSUFFICIENCY IN DOGS

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Abstract
Dogs subjected to double adrenalectomy were treated by intravenous administration of extracts of the adrenal cortex. The criterion adopted to determine the efficacy of the extracts was the effect on the survival period. In a large series of controls the majority of the animals survived 7-10 days, a number less than a week. About 8% survived a fortnight or somewhat longer. Among the animals treated with adrenal extracts about 25% survived beyond the upper limit observed in the controls (18 to 78 days). Of those that did not exceed the survival period of control dogs many reached, or nearly reached, the maximum survival period. In these, as well as in the animals that survived longer, there was mitigation of symptoms and at autopsy the condition of the alimentary canal was found to be much less abnormal.

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