Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite
- 1 December 1991
- journal article
- Published by Elsevier in Toxicology Letters
- Vol. 59 (1-3) , 117-123
- https://doi.org/10.1016/0378-4274(91)90062-b
Abstract
No abstract availableKeywords
This publication has 7 references indexed in Scilit:
- Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metaboliteChemical Research in Toxicology, 1991
- Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in ratsBiochemical and Biophysical Research Communications, 1990
- Metabolic studies on the nigrostriatal toxin MPTP and its MAO B generated dihydropyridinium metabolite MPDP+Chemical Research in Toxicology, 1988
- Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog SynthesisScience, 1983
- Chronic parkinsonism secondary to intravenous injection of meperidine analoguesPsychiatry Research, 1979
- The Metabolism ofN-Ethyl-N-methylaniline by Rabbit Liver Microsomes: The Measurement of Metabolites by Gas-liquid ChromatographyXenobiotica, 1975
- Distribution, excretion and metabolism of neuroleptics of the butyrophenone type: Part I. Excretion and metabolism of haloperidol and nine related butyrophenone-derivatives in the Wistar ratEuropean Journal of Pharmacology, 1967