Synthesis and hypoglycemic activity of N-alkylated hydrazonopropionic acids
- 1 October 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 28 (10) , 1436-1440
- https://doi.org/10.1021/jm00148a011
Abstract
A series of N-alkylated 2-hydrazonopropionic acids have been synthesized and evaluated for their hypoglycemic activity. Most of the compounds exhibit a remarkable blood glucose lowering activity in fasted guinea pigs. Some of the structural variables studied were the effects of branching, unsaturation, or substitution on the alkyl side chain and the effect of nuclear substitution on the aralkyl analogues. From these compounds, 2-[[(E)-2-methyl-3-phenyl-2-propenyl]hydrazono]propionic acid (BM 42304; 42) was selected for further investigation.This publication has 6 references indexed in Scilit:
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