POSSIBLE MECHANISMS OF HYDROCARBON-ASSOCIATED GLOMERULONEPHRITIS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 23  (6) , 294-298
Abstract
Many hydrocarbons have properties which make them candidates for causing glomerulonephritis. They alter most immune functions and create a state of immunity deficiency; damage the tubules which may lead to interstitial fibrosis and increased postglomerular capillary resistance furthering the trapping of macromolecules in the glomeruli; and probably increase tissue permeability to macromolecules. The idea that hydrocarbons cause glomerulonephritis is supported by findings of an association between glomerulonephritis and hydrocarbon exposure, a relationship between tubulointerstitial damage and glomerular filtration rate in glomerulonephritis and immunity deficiency in most subgroups of glomerulonephritis.