Metabolism, excretion and biological availability of 4‘-chloro-2-ethylaminopropiophenone

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Abstract
After oral administration of 4′-chloro-2-ethylaminopropiophenone to man, unchanged drug and the de-ethylated, reduced and reduced deethylated compounds were found in urine. Comparative urinary excretion studies after the oral administration of 4′-chloro-2-ethyl-aminopropiophenone in a sustained release form and in single or divided doses indicates that, when kidney tubular reabsorption is minimized, the biological availability of a drug can be followed by examining the excretion of either unchanged drug or metabolites formed quickly and directly from the administered drug.