PRESSOR SUBSTANCES IN ARTERIAL HYPERTENSION: ACTIVITY AND AMINE CONTENT OF CRUDE EXTRACTS OF BLOOD

Publisher Website
Google Scholar
Abstract
Arterial blood from 23 hypertensive patients and 22 normotensive subjects was drawn directly into alcohol and extracted by various solvents to produce a protein-free fraction. Injn. of this extract intraven. into rats usually caused a prolonged pressor response when the blood was taken from hypertensive patients and usually did not when taken from normotensive ones. The amine content of the extracts was generally increased in hypertensive blood. The active material was inactivated by amine oxidase, was insoluble in petroleum ether and ether. Picrates were formed which were pressor. It is probable that the active material was amine-like in nature. It appeared in larger quantities in cases of "renal" hypertension than in patients with "neurogenic" hypertension.

This publication has 3 references indexed in Scilit: