Excretion of Adrenaline, Noradrenaline, Vanilmandelic Acid and Metanephrines in 64 Patients with Pheochromocytoma

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Abstract
Patients (64) with pheochromocytoma were operated upon. The excretion of adrenaline [epinephrine] and/or noradrenaline [norepinephrine] and their metabolites was high at each observation in 28 subjects with sustained hypertension, 1 patient showing only slightly increased excretion of adrenaline at observation. Another of the hypertensive patients consistently displayed normal amounts of vanilmandelic acid and metanephrines. Most of 28 patients with paroxysmal hypertension showed similar results. In 5 subjects with few attacks, however, normal findings were obtained on 1 or several occasions. Among the remaining patients the excretion of catecholamines was normal in the face of severe hypertension in 2, the high blood pressure being probably due to disease other than pheochromocytoma. Five normotensive subjects without hypertensive attacks presented variable findings. Results from analyses of catecholamines were somewhat more helpful than those from measurements of vanilmandelic acid, which failed completely in 1 hypertensive patient and in 3 others with paroxysmal attacks.

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