Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate

This publication has 20 references indexed in Scilit:

• Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro
  Chemical Research in Toxicology, 1993
• Human erythrocyte glutathione reductase: chemical mechanism and structure of the transition state for hydride transfer
  Biochemistry, 1991
• Glutathione: a vehicle for the transport of chemically reactive metabolites in vivo
  Accounts of Chemical Research, 1991
• Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate
  Chemical Research in Toxicology, 1991
• Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities
  Chemical Research in Toxicology, 1991
• Characterization of the inhibition of glutathione reductase and the recovery of enzyme activity in exponentially growing murine leukemia (11210) cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea
  Biochemical Pharmacology, 1988
• Inhibition of human glutathione reductase by the nitrosourea drugs 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea and 1‐(2‐chloroethyl)‐3‐(2‐hydroxyethyl)‐1‐nitrosourea
  European Journal of Biochemistry, 1988
• Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates
  Biochemical and Biophysical Research Communications, 1978
• Chemistry of nitrosoureas. Decomposition of deuterated 1,3-bis(2-chloroethyl)-1-nitrosourea
  Journal of Medicinal Chemistry, 1976
• Glutathione Reductase from Human Erythrocytes
  European Journal of Biochemistry, 1975